Rafael Leao is expected to return to Milan's XI for the Champions League match against Real Madrid, while Yunus Musah is expected to start on the right wing.
The Reds have three points in the first three Champions League games, while Madrid have six.
Leao sat on the bench for three consecutive Serie A matches, but Paulo Fonseca confirmed in a pre-match press conference on Monday that the Portuguese would start against Merengues.
On the other hand, Real Madrid are without David Alaba, Thibaut Courtois and Dani Carvajal.
Real Madrid-Milan, possible formations
Real Madrid (4-3-3): Lunin; Lucas Vazquez, Militao, Rudiger, Mendy; Valverde, Tchouameni, Bellingham; Rodrygo, Mbappé, Vinicius
Milan (4-2-3-1): Maignan; Emerson Royal, Thiaë, Tomori, Theo Hernandez; Fofana, Reijnders; Musah, Pulisic, Leao; Morata