Luciano Spalletti is set to confirm the same Italy starting line-up that beat France in Paris last month, with Lorenzo Pellegrini behind Mateo Retegui in attack.
The Azzurri won their opening two matches against France and Israel last month and are aiming to win their Nations League group to be among the top teams in the 2026 World Cup qualifying draw.
Spalletti admitted in a press conference before the match on Wednesday that today's match would be "fundamental" for Italy's journey, KosovaPress reports.
Belgium are managed by Italian coach Domenico Tedesco, who confirmed on Wednesday that Napoli ace Romelu Lukaku decided not to join the team as he still needs time to settle in Napoli.
Italy-Belgium, possible formations
Italy (3-5-1-1): Donnarumma; Di Lorenzo, Bastoni, Calafiori; Cambiaso, Frattesi, Ricci, Tonali, Dimarco; Pellegrini; Retegui.
Belgium (4-2-3-1): Casteels; Castagne, Faes, Debast, Theater; Tielemans, Mangala; Lukebakio, Trossard, Doku; I opened.