Milan come into the Coppa Italia quarter-finals looking to shake the bitter taste of suffering a late 1-1 draw at rivals Inter on Sunday. It is now just two wins in five games in all competitions for Sergio Conceicao's side and the clash with Roma will be exceptionally important.
On the other hand, Roma scored late on Sunday to salvage a 1-1 draw at home against Serie A leaders Napoli, extending their impressive run of form to just one defeat in ten games in all competitions (6, draws) meaning Claudio Ranieri's men will almost certainly go into this competition as the safer team of the two.
Roma have also had a long wait for Coppa Italia success, last lifting the trophy in 2008, KosovaPress reported.
The match will take place from 21:00 at "Dan Siro" and these are the possible formations:
Milan (4-2-3-1): Maignan; Walker, Tomori, Pavlovic, Theo; Fofana, Musah; Pulisic, Reijnders, Leao; AbrahamRome: Svilar; Rensch, Hummels, Ndicka; Saelemaekers, Kone, Paredes, Pellegrini, Angelino; Dybala, Dovbyk